QRS Voltage Changes in Heart Failure: A 3-Compartment Mechanistic Model and its Implications

نویسنده

  • John E Madias
چکیده

A 3-compartment mechanistic model is proposed to explain the attenuation of the electrocardiographic QRS complexes (↓QRSV) observed in patients with heart failure (HF). This includes the effects of increased intracardiac blood volume and decreased hematocrit due to blood dilution (1st compartment), the heart's alteration in electrogenesis due to possible ischemia or inflammation, leading to myocardial edema, (2nd compartment), and the passive volume conductor of the tissue and organ constituents of the thorax and the entire body, with their resistivity changes due to increased fluid content (pulmonary and peripheral edema) (3rd compartment). The clinical implications of the model are outlined.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Temporal changes in electrocardiographic frontal QRS-T angle and survival in patients with heart failure

BACKGROUND Heart failure (HF) is associated with considerable mortality. The electrocardiographic frontal QRS-T angle is a simple parameter to measure, reflects changes in the direction of the repolarization sequence and predicts outcome in patients with HF. Data regarding temporal changes in the frontal QRS-T angle in patients with HF and its impact on outcome is limited. AIM To evaluate tem...

متن کامل

Co-administration of Apelin and T4 Protects Inotropic and Chronotropic Changes Occurring in Hypothyroid Rats

BACKGROUND One of the most important thyroid hormone targets is the cardiovascular system. Hemodynamic changes, such as decreased resting heart rate (HR), myocardial contractility, and cardiac output, and increased diastolic pressure and systemic vascular resistance, have been observed in hypothyroid patients. Moreover, in these patients, ECG changes include sinus bradycardia and low voltage co...

متن کامل

Implications of QRS duration in dogs with pacing-induced heart failure.

The objective of this study was to find out the implication of QRS duration in dogs with rapid pacing-induced heart failure. Sixteen Beagle dogs were implanted with transvenous cardiac pacemakers and underwent rapid right ventricular pacing for 3 weeks at 260 bpm to induce heart failure. Dogs were divided into two groups according to the QRS duration: 9 with normal QRS duration (<100 ms) and 7 ...

متن کامل

Low voltage with pericardial effusion: complexity of mechanisms.

Int J Cardiol 1993; 41:141–147 10 Kinoshita O, Kimura G, Kamakura S, et al. Effects of hemodialysis on body surface maps in patients with chronic renal failure. Nephron 1993; 64:580–586 11 Ojanen S, Koobi T, Korhonen P, et al. QRS amplitude and volume changes during hemodialysis. Am J Nephrol 1999; 19:423–427 12 Madias JE, Narayan V. Augmentation of the amplitude of electrocardiographic QRS com...

متن کامل

  Background & Objective : Heart failure is a clinical syndrome and increases in rate by aging. Because changes in ECG and electrolytes are variable, specific and sometimes independent to the disease with different methods to be diagnosed, in this study we tried to find a way to diagnose them.   Materials & Methods: This is a retrospective descriptive-analytic study. Data was collected from dec...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2010